Overall, our study outcomes demonstrate that the genetic complexity of human eye color considerably exceeds previous knowledge and expectations, highlighting eye color as a genetically highly complex human trait. Our findings collectively explain 53.2% (95% confidence interval, 45.4 to 61.0%) of eye color variation using common single-nucleotide polymorphisms. Further analyses in 1636 Asian participants from two populations suggest that iris pigmentation variation in Asians is genetically similar to Europeans, albeit with smaller effect sizes. We find evidence for genes involved in melanin pigmentation, but we also find associations with genes involved in iris morphology and structure. We identify 124 independent associations arising from 61 discrete genomic regions, including 50 previously unidentified. ![]() We report the results of the largest genome-wide association study for eye color to date, involving up to 192,986 European participants from 10 populations. Human eye color is highly heritable, but its genetic architecture is not yet fully understood. Martin, Ching-Yu Cheng, the 23andMe Research Team, the International Visible Trait Genetics Consortium, David A. van Duijn, Tamar Nijsten, Jiali Han, David A. Hammond, Yuan Shi, Yan Chen, Changqing Zeng, Caroline C. Medland, Dragana Vuckovic, Giorgia Girotto, Cinzia Sala, Eulalia Catamo, Maria Pina Concas, Marco Brumat, Paolo Gasparini, Daniela Toniolo, Massimiliano Cocca, Antonietta Robino, Seyhan Yazar, Alex Hewitt, Wenting Wu, Peter Kraft, Christopher J. Ring, … Show All …, George Davey Smith, David L. ![]() Whether you’re looking to add volume, length, or a splash of color, you can achieve the hair of your dreams with Prota Hair.įor many years Supreme Hair has been in the alternative hair business and now is recognized as one of the leading hair suppliers of quality hair products worldwide. With a strong catalog of well sought after hair extensions it is no wonder salon officials worldwide call Supreme Hair when they want to please their clients.Mark Simcoe, Ana Valdes, Fan Liu, Nicholas A. Prota hair is available in a variety of different styles, textures, lengths, and colors, which makes it easier to find a perfect match to your natural hair. By spraying the hair with water and lightly combing through, the unique rebuilding nature of Prota is activated, and is instantly refreshed and restored, just like human hair.Because Prota hair is made with Ultima Organic Protein, the hair retains moisture so that it is soft and easy to manage.Less tangling, easy to restore and flame retardant. ![]()
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